Yes, but not in an offensive way. I've had sexual relations with a guy that had down syndrome. He worked at the pizza hut near where I grew up and lived down the street. I think people tend to either view the mentally handicap as disgusting or frightening, or they turn them into forever children. The guy I slept with had his own place, job, and while I wouldn't say his ideas were burning up the firmament with abstract genius, he did have his own ideas/opinions etc -- he was also silly and honest. Overall, cool person, slightly annoying at times, but that describes most people. There was definitely some element of novelty involved in the choice as I wouldn't say people with down syndrome strike me as strongly sexually attractive. I was curious about him as a person and lover. Sex wasn't very good.
The world is filled with a lot of people that operate within a very rigid and narrow worldview. They are frightened of anything outside that narrow conception of the world. So they lump people into these categories of repulsive, good, beautiful, etc. without seeing there is a ton of overlap between all these qualities -- that dependent on mindset and perspective you can see something repulsive and beautiful in everyone. This is what makes life so compelling. How's that for an NF answer?