Universal justice and fairness include "niche sexual preferences", as well as what I suppose you would call "niche religious preferences" like being Jewish (2.4% of US population), which really is a preference vs. something hardwired into our makeup, like being black, gay, female, or disabled. As long as any group is limited or excluded based purely on who they are, we do not have that universal fairness. The smaller groups make good targets because 1) they are not a large enough voting block, so no risk alienating them, and 2) many people will not personally know anyone in the group, so can more easily be manipulated into fearing or even hating them.
Put another way, the downside of majority rule is the possibility of oppressing minorities. Progressive government includes protections to ensure that does not happen. The smallest, most "niche" group, to use your terminology, becomes the canary in the mine shaft. As long as they are treated fairly, everyone else probably is, too. Once it becomes OK to limit, bully, or oppress them, it's just a matter of time before the next group comes under attack, and the next, and the next.
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