- Dec 29, 2007
- MBTI Type
The fluorine in the prozac molecule is on a CF3 group which means that it is not breaking up into F- anions in your body. The C-F bond is extremely strong - Carbonâ€“fluorine bond - Wikipedia, the free encyclopedia
Hi Spin, taking wiki is fine though its much more complex than that. I knew that you would take this as a challenge, however it takes lots of energy for me to debate properly. This is a very important topic for me except I am done discussing for now. I would like to point out that earlier I pointed out that anti depressants use the adrenal glands as a trigger to release serotonin as a cortisol stress response. I do want to say I still disagree with the focus. And I tend to think hormones are part of the same or similar chemistry of the brain, that is to say nothing in the body is exclusive and isolated. And unfortunately people tend to think much of what goes on in the body is isolated, a tenancy to assume just because the point at which the neurotransmitters release is different than hormones means that the trigger point must be neurotransmitters solely responsible in governing the functionality of mental health. I am doubtful. I believe there is a correlation that people are missing between the way the endocrine system functions and the way the brain and neurotransmitters function but that's just me.
And no, in the case of plastics most consumer products are not safe, and I would disagree with your thoughts about fluorine and plastic however that is going off topic slightly since Aphrodite-gone-awry wants to know whether depression is a benefit in disguise or not.
And I said no that there are no benefits to depression. And then I went into presenting reasons why depression happens because this is a topic that I am passionate about since it has affected me greatly and the prospects of life have been limited by its effect. However depression does generate a different kind of creativity. And the kind of writing I used to do was incredible, and maybe that is part benefit, where depression activates parts of the brain that heighten the emotional and intellectual extremes in artistic integrity, be it through the media, film, literature and art forms that would normally not be there in the same way had a person been happy. At the expense of living a proper and healthy life.
Thyroid hormones as neurotransmitters.
During brain development, before the apparatus of neurotransmission has been set into place, many neurotransmitters act as growth regulators. In adult brain, their role in neurotransmission comes to the fore but neuronal plasticity and other growth-related processes are their continuing responsibility. This has been clearly demonstrated for catecholamines. Previous as well as recent evidence now indicates that thyroid hormones may participate in the developing and adult brain through similar mechanisms. Immunohistochemical mapping of brain triiodothyronine (antibody specificity established by numerous appropriate tests) demonstrated that the hormone was concentrated in both noradrenergic centers and noradrenergic projection sites. In the centers (locus coeruleus and lateral tegmental system) triiodothyronine staining, like that of tyrosine hydroxylase, was heavily concentrated in cytosol and cell processes. By contrast, in noradrenergic targets, label was most prominent in cell nuclei. Combined biochemical and morphologic data allows a construct of thyroid hormone circuitry to unfold: The locus coeruleus is conveniently located just beneath the ependyma of the 4th ventricle. Thyroxine, entering the brain via the choroid plexus, is preferentially delivered to subependymal brain structures. High concentrations of locus coeruleus norepinephrine promote active conversion of thyroxine to triiodothyronine, leading to the preeminence of the locus coeruleus as a site of triiodothyronine concentration. Results of treatment with the locus coeruleus neurotoxin DSP-4 established that axonal transport accounts for delivery of both triiodothyronine and norepinephrine from locus coeruleus to noradrenergic terminal fields. The apparatus for transduction of thyronergic and noradrenergic signals at both membrane and nuclear sites resides in the postsynaptic target cells. Upon internalization of hormone in post-synaptic target cells, genomic effects of triiodothyronine, norepinephrine, and/or their second messengers are possible and expected. The evidence establishes a direct morphologic connection between central thyronergic and noradrenergic systems, supporting earlier proposals that triiodothyronine or its proximate metabolites may serve as cotransmitters with norepinephrine in the adrenergic nervous system.
Cotransmitters sounds much more plausible in my mind.