It's best to get over the latter of those things so that we can branch out and do the former of those things. That can be a huge psychological hurdle, for sure. It's easier to stick to what you know, since that, from an unhealthy perspective, validates your self-worth as a human being.
Generally.
I'm talking about learning new skills and trying (obviously not stupid) things. Stuff that, deep down, you really want to try, do, or master. That doesn't apply to some of the stuff y'all have posted, of course, such as sawing your arm off.
Also, if you're going to try to saw your arm off, you'd probably be better off failing to do it.