Great topic. Finding a career that works is very important, yet understanding what will work for anyone is difficult.
I have a friend that went right into a job after college and grad school and were happy from day one, at the same employer, working in the same exact subject area. I have another friend that backed into a career that was really just a part time job not in the field he desired that now they is extremely well compensated 20+ years at a top 100 corporation.
Not my path, unfortunately. I am currently sitting at my very good paying job that I completely despise, trying to figure a way out. It takes so little of my skills and talents and is dehumanizing to say the least.
I have had two major careers, neither really similar to the other, each with major drawbacks. These two careers were ones I had picked as a child. I reached my goals and was very disappointed. I see now that most of the problems in the careers relate to me and that finding myself will help me to better find happiness in work.
My thoughts on jobs:
There are many different jobs in a given career. In my youth, I had some good fitting jobs but for horrible employers. The environment was awful. I should have just tried to find a good environment, but at the time I couldn't see that I blamed the job for the sins of the bosses.
I ended up radically changing jobs inside that career. I was warned by a mentor that kill my soul, but I did it anyway. And he was right. I moved to a less people oriented position and became extremely unhappy, so much so that I wanted to completely change careers.
In the background of all this was that I had an unpleasant childhood that left me with scars and blinded me to myself.
So, I hit my mid thirties and was depressed and didn't know the cause. I blamed my career, which could have been solved with modest changes in the job, but I didn't do that.
Instead, I pursued radical change to my other career. It brought about short term happiness, but once there, I encountered other pitfalls and disliked it.
So, I went back to my old career, but in a different job, one I hate. I said it was only short term, but that started 4 years ago. .... and I still haven't moved on.
Several mentors have suggested yet a third career for me, that would sort of combine the first two. It could work, or just turn out like the last two careers. I am looking primarily at new jobs in my first career, jobs that I know would provide good job satisfaction and use a healthy portion of my talents, but the third career would seem like a golden fit.
Additionally, I need a career that provides value to the world. So there are many jobs in these careers I couldn't do, as I have learned from experience. My current position is empty and soulless and the sooner I leave the better.