All the time; once something has become mundane, tedious, or repititively dull, I often will desire to attempt something new. Whether this be school, an activity, a daily routine, whatever, all that matters is being able to try out or see something different.
One vivid example I could suggest would be when my family and I moved cross country from New Jersey to Washington. Although the first half of the trip was slightly unpleasant to me, the second half (Rapid City, South Dakota onwards) of the trip was magnificent, there were all sorts of new things to see, and the whole journey was quite the experince. In addition to that the change of secnery and lifestyle from NJ was refreshing and invigorating; I remember that once my family and I had found a house, that for the first few months at least, there was a strange and almost indescribable feeling to me concerning my external atmospphere. I really don't know how to explain it, but it felt as though I had become in sync with my new home and lifestyle, like that great feeling one gets when they cleanse their body after a shower.
EDIT: yay 300th post!