I don't know why.. but the first thing I thought of was Elvis. Elvis, by today's standards, is pretty "normal" and mainstream. When he was young though, he was an oddball. As a teen, he apparently got strange looks, in the same way someone like Prince gets them today. Elvis' favorite colors were pink and black.. already different enough. But he went across town in downtown Memphis, where all the pimps shopped, and got his clothes there. He bypassed the typical cropped or buzzed hair of the day and grew it out. He was a big fan of the comic book character Captain Marvel.. he wanted his bangs to dangle like Captain Marvel. He played a bunch of hootenanny country mixed with African American blues, and wanted to sound like Dean Martin. He was not a normal kid in school. But now, everyone sees the things Elvis did as a more or less common now.
Fast forward to the early 70s. There was a story from Elvis' girlfriend at the time.. she said they were watching some music show, and some glam rock band came on. I don't know who it was, but there was a lot of bands dolling it up by then. He turned to his girlfriend and kind of facepalmed.. "Did I cause this?" At that point, even he couldn't adapt. But culture as a whole did. Elvis himself died not long afterwards.
Anyways, if you just mean genetics, I don't know what to say. I think this one guy ushered in a lot cultural diversity/expression/openmindedness what have you.