Wow. I played for a few hours last night.
With the opening sequence, I was afraid I wouldn't even get to customize my character, but you get to do that after... still, you're stuck being human, vs another race.
The game's look and feel is VERY different, so much that I didn't really recognize the franchise aside from places and races, etc. Everything has been redone, moving away from the typical clutter/packrat style of most computer-game RPGs to an open and clean style.
The talent trees are webs, now, rather than groups with linear streams of talents within them, so you can get to later talents by different routes, and upgrades are simply spoked off the talent in question.
The dialogue wheel seems less complicated than speaking options in DA, and the options are not verbatim what the character says. You need sound for this (although I assume there's a subtitling option somewhere); your character talks, dialogue actually happens in real-time.
Inventory is not one long linear list, it's more intuitively separated into groups, and as far as plants and resources go (by which to fashion potions, poisons, runes, etc.) you only need to find one of the item in question, after which point the resource is open. So you don't have to constantly refill and clutter your inventory with lots of mats.
I think overall the game feels much more suited for console (in style) than computer, it's mean to be clean, easy, visually intuitive, rather than feeling more cluttered and complicated. The hotkeys, while the same concept, seem more ironic in nature. The action also feels much faster to me, and that took a little bit to get used to.
And, after I dumped her first few points into the Fire/Ice web, Bethany (mage) is a freaking badass! The first time she did cone/arc of cold and immediately splattered six baddies at one time, I was just kind of amazed. Fireball and Cone of Cold are devastating. At the moment, while I have Hawke specced as a rogue and she does some great one-on-one damage, the main strategy of my group seems to be distracting any incoming mobs so that Bethany can take them all out without getting hit.
I also recognized a character right away from DA (at the end of the intro / escape sequence), despite appearing much different than the character did in that game; it was the voice that gave things away. I think the actor's voice-acting was better directed this time as well; some of the lines had sounded a bit stilted in DA, but this time the acting was very natural and intriguing.