PLoS ONE: Pancreatic Insulin Content Regulation by the Estrogen Receptor ERα
...In addition to the role that estrogen receptors may play in the physiology of pancreatic β-cells, we should bear in mind that any disruption of β-cell physiology is associated with the development of type II diabetes mellitus. Indeed, recent epidemiological reports link the existence of endocrine disrupting chemicals (EDCs) in blood, such as persistant organic pollutants (POPs) [8] and phthalates [9], with type II diabetes and insulin resistance. In particular, the estrogenic pollutant Bisphenol-A (BPA) was described as altering pancreatic β-cell function and blood glucose homeostasis in mice [10].... much more at link