Oh, yeah.
I've been told that I regularly operate at around 75% (or less) of what my 'normal' capacity should be, because of mental conditions. The right combination of medication would help me reach 'normal,' and I get glimpses of it from time to time. So, reaching 'normal' for me winds up feeling like reaching transhuman because I'm just flat-out not used to it. When I'm manic--yeah, even moreso.
I have often wondered whether or not I would be completely satisfied with that 'normal.' My 'natural state' without the right medication is all sorts of 'bad'--suboptimal, unproductive (in my estimation; the world seems quite content with it, though), miserable--so I don't regard the natural state as something to shoot for.
I would regard anything that makes us mentally stronger and more adept as fair game, so long as the side effects don't burn us out (yeah, that's a bitch). I would love to at least experiment with those sorts of enhancements. Even if I'm not on them for long, I would still learn from the experience, at least.
I would want these sorts of enhancements to be available publicly, though, for our mutual betterment. Lots of people benefit from being a Google/Wikipedia away from a wealth of information, from generic drugs at ~$4/month, etc.
In another life, I would have been one of those hippies who experimented with all sorts of illegal drugs just to gain the perspectives that they provided.