It's a running theory of mine that an ESTP will try any drug or substance known to man, if they are in the same room as the people who are using it.
In fact, I've seen an ESTP try a very powerful psychedelic (2c-e, a research chemical that no one really knows much about) with no knowledge about what it is and only after a few seconds of someone talking them into it.
I think it might be more of a Perceiver thing due to our open mind, and less of a Judger because they need structure. Drug's don't have much structure to them considering that every time you take them it could be a different experience.
I had a drug problem for a few years. Combination of living away from my parents for the first time, being around tons of drugs, and being depressed. I was usually at the forefront of trying new and crazy things when it comes to chemicals.
Who wants to try a bottle of merc's "Extroversion Olive Oil?"