No. Regardless of whether or not souls exist, I wouldn't go for total knowledge for two reasons:
Part of what I like about life is the joy of discovery and the bliss of ignorance. I actually enjoy delving into absurdity. A predictable, complete world would be less fun.
Secondly, I am often disturbed by the little extra insights into the nature of things that I sometimes have. Even if I was aware of all things, there's no way I could stop time and right all wrongs, even for those unlucky few that I actually care about.
Absolute knowledge would likely bring an all-powerful existential depression in the face of my own impotence. Or, if possible, it would awaken a desire to use my knowledge to increase the universal chaos factor.
On the other hand, if I were to pick between me getting all the knowledge of the universe versus anyone else, I'd pick me. I can't think of a single person who I'd actually trust with such an ability.