Like others have said, if I don't like you, I probably won't waste my energy bantering with you, and probably wouldn't care enough to try to come up with a way to make you look/feel stupid. I just disconnect and try to excuse myself.
Every once in a while, someone rubs me the wrong way--maybe they're being obnoxious, or hurtful themselves, or just ignorant. In those cases, I might say something that would poke holes in their argument, to let them know they're not fooling me. But I never, and I mean NEVER, make intentionally hurtful comments. I never make a comment with the intent of hurting or harming a person's self-esteem. That's just spiteful, immature behavior.