I realize this is an old thread (found it as a cross-reference from another one), but wanted to chime in with my personal experience.
I was married to an ISFJ for 16 1/2 years. It started well and ended badly. Looking back, the biggest conflict was the N/S thing - he used to swear I could "see around corners," which caused real problems especially toward the end when he had a lot of things he wanted to hide. (He now has problems in this area with our son, who is also an N.)
The fact that he had a very unhealthy relationship with his mother didn't exactly help matters, but that was only type-related in that ultimately he felt more of a loyalty to her (blood family) than he did to me.
I believe that he is married to another S now.