Whenever I go for a drive, or leave the immediate community I live in for any reason and any amount of time (however little,) I get this strange "feeling," and it takes a while after I've returned home for it to abate. It's not necessarily a "bad" feeling; I guess "foreign" would be the most appropriate adjective. I don't have to have been gone for long at all, even just a half hour or so. I've noticed that the time it takes for the feeling to dissipate is proportional to the time I've been gone from home.
What I mean is that I don't, internally, "feel home" even if I am, physically--like mind/body discord.
I don't think it is that normal sense of unfamiliarity that comes with being some place you're not used to...it seems more than that, but perhaps not. I don't know.
Do you experience this as well?