The shows that I've liked the most have had something in common: I generally like shows where there is one true central character (as opposed to a family or a group) and where he/she is somewhat of a loner and/or the show gives a lot of insight and depth into what the person is thinking or feeling inside of themselves.
That's hilarious because some of my favorite TV shows are:
The Big Bang Theory
Dharma & Greg
The Wonder Years
Saved By the Bell
Shows with personality insight are my favorite, or where they have some type of internal dialog discussing their experiences.