Weed for the effect (have to love what it does for my joint pain) and no drawbacks like hang-over or feeling sick. The damn smell and taste, though...gah. Even so, it would be nice to do again.
Alcohol, well, wine is very nice. Especially with my abnormally acute sense of smell. I can only drink about 2 glasses before I start to feel fuzzed and a little sick. I get horrible vertigo when I go over 3 glasses (or 2 with no food) so I am a little leery.