I ask this of genuine curiosity, knowing that there are people posting on this board who are knowledgeable in such matters and further knowing that we are a speculative bunch:
What's all of this you hear about alcohol (amongst other things) killing brain cells? If that was the case, why am, er, IS my, er, twin brother wink not retarded by now?
Well, most of us that post here are pretty smart, I'm sure we have enough to spare. To use military parlance, the good times alcohol brings surely place those deceased brain cells in the category of "acceptable losses".
On the other hand, if ignorance really is bliss, then drink yourself stupid!