-- well, before we get into that, my inspiration is that a TV at Schlotzky's clued me in to the fact that this existed.
I figured that any one of us could do a better job, and any one of us would have a better rationale for actually having a show in the first place.
That said... if you hosted a talk show, which forum members would you have as guests?
Among others, I could see a few recurring guests.
First, I'd have @RaptorWizard. I'd ask one very short, open-ended lead-in question, then let him talk nonstop for around an hour. Rather than split the show naturally by where commercial breaks would be, we'd film the episode nonstop, then insert the breaks in after the fact so as to not break up the flow.
Second, @Juice. We'd talk hypothetical dilemmas. But for kicks, we'd put audience members on the spot. We'd have four of them lie next to one another on the floor, with a loose stage light tottering right above them; have another one lie down out of harm's way; and yet another one choose whether to swivel the light so that it crushes the one instead of the currently-damned four. We'd have a several audience members in cages and several other audience members with riot batons, then let them do what they're gonna do for the whole hour; and we would make liberal use of the "applause" sign. I guess we could also sew people together if we got them to sign some hefty waivers.
@FDG could be on for similar experiments in behavioral economics. In these segments, we'd change it up and turn the whole thing into a game show, with a few lucky members of the audience getting chosen to come up to bat, The Price is Right style. FDG and/or I would be their opponent, Win Ben Stein's Money style. The winning prize for each game would be $10,000. Most of the time, though, the game we'd play would be the "ultimatum game."
You could also talk about your show's set backdrop and target audience or whatever, but nobody will care but you.
(My set would be plain but pompously elegant, overtly aimed at an audience sorta-kinda like Bill Maher's; but in reality aimed at an audience more akin to Gallagher's.)