I personally believe in organizing just enough that minor things in life aren't a total pain in the ass. As an example of this, I organize my medicine cabinet into bins for "weekly medications," "cold meds," "headache meds," and so on, but I don't go so far as to alphabetize my medications. Once in a while I'll apply a more "strict" organization, knowing and accepting full well that it'll decay slightly but that it'll save me even more effort for a little while.
I also use Google Calendar to keep track of my appointments and events, and I have a few Google Tasks lists of things to buy and things that I need to do. These sync "across the cloud" (lol) to all of my devices.
In addition, my mind is a jumble and I can be fairly absent-minded. So, if I think of something, I want to record it right then and there so I don't have to remember it later.
More embarrassingly, I modified the userChrome.css to give me a dark tab for "new tab"s, which I use as separators for topics or ideas. (I've tried Tab Mix Plus, etc. -- not my thing.)
The point is that thinkin' a bit right now (e.g. organizing or writing something down) saves me a lot of thinkin' later (e.g. remembering something or sifting through piles of stuff). Things that can think for me at lower levels so that I don't have to worry about lower-level thought are also great. But these organizational systems aren't often ends in and of themselves for me.
What do you do to stay organized? Do you use mind maps or checklists? In particular, have you found a good set of software that helps you stay on track? Or do you prefer pen and paper methods?