While there are antagonists that I find awesome precisely because they disgust me, I'll list those characters I just plain want to die in a fire:
In no particular order...
1) Pretty much every
annoying immature irresponsible"quirky" character (hello, indie films!)
2) Jerry (Tom & Jerry)
3) The Herrera siblings (Heroes)
4) Laurie Forman (That '70s Show)
5) Lucy Van Pelt (Peanuts)
6) Jason Fox (FoxTrot) - Hell, the entire family is insufferable at times. Love the strip, tho.
7) Patrick Jane (The Mentalist) - Sorry, but I can't stand him.
8) Sheldon Cooper (The Big Bang Theory) - God, I hate arrogant people... >.<
9) Les Moore (Funky Winkerbean) - Knew him through the Comics Curmudgeon blog.
10) Calvin (Calvin & Hobbes)