I'm extroverted myself but come on, some people really need to learn the concept of awareness. If you don't see the other person responding or struggling, give them a minute to think! Give yourself a moment to breath. Maybe change the subject. And I think it's a really selfish act when some extroverts just keep their mouths running because they're afraid of the silence. Annoys me to no end. The way I deal with it is either tell them to shut up or I clam up and give them a murderous look that clearly signals I'm not gonna engage you anymore.
But in all fairness the same, but reversed principle goes out to the really introverted people as well. We should all try and meet halfways in a tango.