Yale Scientists Reverse Type 2 Diabetes in Rats
We know what the toxic levels are and we know this cheap chemical can reverse Type 2 diabetes. Let's fast track this baby and get it out to the masses. This is exactly the type of research that DIYers or biohackers would love to work on.Based on their earlier studies, the researchers determined that toxicity associated with the agent -- mitochondrial protonophore 2,4-dinitrophenol (DNP) -- was related to its peak plasma concentrations. They discovered that DNP's efficacy in reducing liver fat and liver inflammation could be achieved with plasma concentrations that were more than a 100-fold less than the toxic levels.
In my opinion, if it's safe in rats and if there are human volunteers, then the drug should be available for general use provided that the public is warned that it hasn't gone through clinical trials.In the next phase of the study, Shulman and his team developed a new oral, controlled-release form of DNP, known as CRMP, which maintained the drug at concentrations that were more than a 100-fold lower than the toxic threshold. Administered once daily, CRMP delivered similar positive results, reversing fatty liver, insulin resistance, and hyperglycemia in rat models of NAFLD and type 2 diabetes, as well as liver inflammation and liver fibrosis in a rodent model of NASH, with no adverse effects.