Details of a new vision for America's space programme are expected on Monday.
It is widely thought the new approach will see the commercial sector being given the task of launching astronauts.
In doing so, President Obama will scrap the rockets currently being developed by the US space agency to replace the shuttle and go back to the Moon.
It is anticipated Nasa chief Charlie Bolden will outline the new vision to coincide with Mr Obama's 2011 budget request to Congress.
Pre-announcement briefings have trailed the likelihood of the agency getting a $6bn increase in its funding over the next five years.
Some of this money will be used by Nasa to incentivise private companies, to help them bring forward a new generation of launchers to carry humans into orbit.
As well as being a customer for these rockets, the agency would also set and oversee standards in the nascent market, especially in matters that concern crew safety.
In addition, the funding boost would enable America to extend the operation of the International Space Station from 2015 to at least 2020.