He really does care about the cases he takes on. You see that a lot.
That's true enough but that's simple caring... that's not ISFJ. I'd expect some kind of reference to socially excepted norms with an ISFJ shadow yet I've seen none. He appears to treat such things with distain.
Now you could make a case for that being part of the self loathing but I've never seen any sense of anger towards the norms... just distain of them getting in the way of logical progress.
I'm watching it now- it's a rerun but I missed it when it was shown before. He's helping this doctor in Antactica and her self-exam over webcam is the best thing I've seen in ages.
I don't know where you people are getting introvert here!
I love that episode.
But for argument's sake....
There is a lot of distance between the two of them though and that could make the interaction safe. Doesn't he decline the chance to get naked as well? (I may have made that up.) He's intimate with her, but it's not the same as a face to face interaction. How often is he openly intimate and physically close to someone in face to face interactions?
One could even argue that his outgoing and aggressive traits are used to keep people at a distance. It's a preemptive bark, so people stay away. It's lonely when you're at the top and House is at the top of most things and social situations.