Certainly the strongest motivation to keep an organism alive is pleasure. The role of pleasure is to inspire the organism to perform actions to survive and reproduce. Any activity whose deprivation causes us such a lack of pleasure in us that we act irrationally and even maniacally to its absence is an addiction.
We should overcome our irrational addictions for life and all stupid nature mechanisms that preclude us from seeing the truth of reality.
Also, death is the endpoint uncovered by the quest to overcome prejudice in the name of enlightenment.