Think for a moment of the inverted pyramid that sits behind you.
You are here, and behind you are thousands of generations of your ancestors. Each one strove to find someone (or thing) to mate with, and each time succeeded despite the odds, to do so before dying.
Each time, one of your ancestral sperm outswam all the others, mated, and survived childbirth, childhood and an uncaring universe.
Every generation behind you succeeded, right back to crawling out of the ocean. Millions of ancestors in a pyramid, and right at the bottom : you.
To even start this process, the right soup had to be created, the right molecules bang together in the right circumstances to kickstart life. Yes, this is all arguable.
Think of all this. Are you as a result significant? Or is this simply emergence/chaos theory at work? Are you simply the emergence out of the chaos of a million billion striving organisms in random effect? Does your existence despite all the odds signify something?
My answer : I must be. All those cumulative generations created me, I must be significant. Surely. Aren't I?