This's regarded by some religions, and several ideologies, as the stepping stone to all else. After giving it a little thought, I think I've actually already been doing so without realizing it consciously.
The basic idea, is that yeu know nothing; to understand or learn anything, yeu must first accept this, and understand that yeu truly do not know anything. One cannot correct a problem until the problem has been admitted to and identified.
Now that being said, we have a starting point to work with, similar to the "I think, therefore I am" starting point. Except... we can't really PROVE we think. We may believe such, but such can also be mere illusion and assumption. I've never truly had my thought process actively work, so much as it just magically comes up with related information and makes conclusions based on the information, but there's no real 'thinking' involved, it just happens. It's quite strange when yeu stop to try to think about the actual process...
Now that being said, we're stuck with knowing nothing. We can't even prove we exist, nor that we think. Great. So we have nothing at all.
And therein we can use that to determine that if we don't know anything, then we have no basis to assume that we know whot isn't either; we don't know that magic doesn't exist, that god is real, or that we aren't all linked to some hive mind a la the matrix. We have no clue whot is real, which means anything is possible.
Therefore, we can only rule based on whot seems most plausible, under the assumption that the information presented to us is accurate.
Our senses can be deceived, our minds can hallucinate or play tricks on us, our memories are largely just key points that get 'filled in' with guesstimates as needed.
Due to this, we really can only state whot we believe to be true, given this rather shaky foundation to work with.
Furthermore, this acceptance of our ignorance of reality as a whole, would put us on much better grounds to deal with people. We wouldn't really have racism because we would be able to accept that we flat out don't know anything about that person; all we have are assumptions. We wouldn't need ideological wars, as we would be able to accept others' viewpoints as merely a seperate interpretation, possibly due to having different information.
And most importantly, we'd be able to get over the concept of "knowing the truth".
Too many times we believe we "KNOW" whot god wants. Whot the heavans demand, that there is no afterlife, that we have a purpose and a destiny, and that everyone who disagrees is wrong.
Once we learn that we really flat out don't "KNOW" anything, maybe we can stop dealing in absolutes that only cause harm, and accept that there may be things out there beyond our understanding, and beyond our knowledge base.
Or maybe it's just late at night, I'm bored, and felt like ranting. Whichever.