Origin of YAP+ lineages of the human Y-chromosome
Am J Phys Anthropol. 2000 Jun;112(2):149-58. Related Articles, Links Click here to read Origin of YAP+ lineages of the human Y-chromosome. Bravi CM, Bailliet G, Martinez-Marignac VL, Bianchi NO. Multidisciplinary Institute of Cell Biology (IMBICE), 1900 La Plata, Argentina.
We screened a total of 841 Y-chromosomes representing 36 human populations of wide geographical distribution for the presence of a Y-specific Alu insert (YAP+ chromosomes). The Alu element was found in 77 cases. We tested 5 biallelic and 8 polyallelic markers in 70 out of the 77 YAP+ chromosomes. We could identify the existence of a hierarchical and chronological structuring of ancestral and derived YAP+ lineages, giving rise to 4 haplogroups, 14 subhaplogroups and 60 haplotypes. Moreover, we propose a monophyletic origin for each one of the YAP+ lineages. Out-of-Africa and out-of-Asia models have been suggested to explain the origin
In this article, only three asian groups (Japanese, Tibetan, Jew)
, african, and a few European have a genetic marker YAP+ on the non-recombining portion of Y-chromosomes.
Tibetan (Central Asian): 1 out of 1 sample
Japanese: 4 out of 13 samples
Chinese: 0 out of 23 samples
Laotian: 0 of 7 samples
Cambodian: 0 out of 3 samples
South East Asians: 0 out of 16 samples
South Asians: 0 out of 152 samples
Jews: 4 out of 18 samples
Lebanese: 0 out of 2 samples
Syrian: 0 out of 6 samples
Melanesian: 0 out of 2 samples
African: 37 out of 72 samples
European: 3 out of 68 samples
Multiple origins of Tibetan Y chromosomes.Qian Y, Qian B, Su B, Yu J, Ke Y, Chu Z, Shi L, Lu D, Chu J, Jin L. Institute of Medical Biology, The Chinese Academy of Medical Sciences, Kunming, Yunnan, China.
The genetic origin of Tibetans was investigated using Y chromosome markers. A total of three populations were studied, two from central Tibet speaking central Tibetan and one from Yunnan speaking Kham. Two dominant paternal lineages (>80%) were identified in all three populations with one possibly from central Asia (YAP+) and the other from east Asia (M122C). We conclude that Tibetan Y chromosomes may have been derived from two different gene pools, given the virtual absence of M122C in central Asia and YAP+ in east Asia, with drift an unlikely mechanism accounting for these observations.
PMID: 10830914 [PubMed - indexed for MEDLINE]