high levels of estrogen can cause reduced
levels of testosterone, fatigue, loss of muscle tone, increased body
fat, loss of libido and sexual function and an enlarged prostate.
Other problems associated with excessive levels of estrogen include
(1) The shut down of normal testicular production of testosterone.
Excess estrogen can saturate testosterone receptors in the
hypothalamus in the brain therefore reducing the signal sent to the
pituitary gland. This in turn reduces the secretion of luteinizing
hormone, which is necessary for the gonads to produce testosterone.
(2) Increasing the body's production of sex hormone-binding globulin
(SHBG). SHBG binds testosterone therefore reducing the amount of the
clinical important free testosterone in the blood available to cell
(3) A reduced effectiveness of the testosterone replacement therapy
due to excess aromatization of testosterone medications to estrogen.
(4) Long-term health risks including an increased risk of diabetes,
heart disease, and some cancers.