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  1. #101
    Senior Member Mal12345's Avatar
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    same: Uses, Side Effects, Interactions and Warnings - WebMD

    "SAMe is a chemical that is found naturally in the body. It can also be made in the laboratory.

    SAMe has been available as a dietary supplement in the US since 1999, but it has been used as a prescription drug in Italy since 1979, in Spain since 1985, and in Germany since 1989. Researchers discovered the potential usefulness of SAMe for treating osteoarthritis by accident. They were studying SAMe’s effect on depression when the patients they were following reported an unexpected improvement in their osteoarthritis symptoms.

    SAMe is used for depression, anxiety, heart disease, fibromyalgia, osteoarthritis, bursitis, tendonitis, chronic lower back pain, dementia, Alzheimer's disease, slowing the aging process, chronic fatigue syndrome (CFS), improving intellectual performance, liver disease, and Parkinson's disease. It is also used for attention deficit-hyperactivity disorder (ADHD), multiple sclerosis, spinal cord injury, seizures, migraineheadache, and lead poisoning.

    Some women use SAMe for premenstrual syndrome (PMS) and a more severe form of PMS called premenstrual dysphoric disorder (PMDD).

    How does it work?
    The body uses SAMe to make certain chemicals in the body that play a role in pain, depression, liver disease, and other conditions. People who don’t make enough SAMe naturally may be helped by taking SAMe as a supplement."



    This drug is a minor miracle. I found it online while researching fibromyalgia. It also has other benefits mentioned above. I love this stuff. I feel so much better taking it.

    It started one day in 2012 when I woke up in pain. My joints hurt, my muscles hurt, I hurt clear down to the very bone.
    The pain may have been building up for a while and then gotten bad enough to be noticeable. Or maybe it just happened over night. But I didn't have medical insurance and could only afford the cheapest clinic "doctors" (for lack of a better word). I was given a diagnosis. And although it holds true for certain symptoms it didn't go far enough. It didn't explain all my symptoms.

    I started this thread somewhat over a year after my symptoms began. The "Logan" (his real name) in the OP is just one of many of a new breed of "doctors" who exist merely to generate money for clinics, pharmacies, and drug companies by keeping their patients on a merry-go-round of pharmaceuticals and frequent "med check" clinic visits. Their patients are little more than walking money to them. Keeping the patients sick but still alive, and spending money, is their goal in life.

    This problem goes back to the 1980s when some socially damaging gubmint legislation was put into effect that detrimentally affected the way doctors go about their business of healing the sick.

    In 2013 I was prescribed 1600 mg of Ibuprofen otc per day for pain. That's a lot of drugs. Seeing the hopelessness of the situation, and knowing that clinics are useless, I went on my own and started going 'alternative.'

    I started very basic - I paid more attention to gum health. After a few months, the general malaise had decreased by a good 80%. I said goodbye to the constant Ibuprofen, although I still take it for random aches and pains. But there were still problems, so I started experimenting with various alternative medicines, nothing too crazy. And I always did my homework at webpages such as webmd before jumping into a new regimen.

    I started taking a zinc/magnesium combination which is good for the immune system. I haven't had a sick day since 2013 when I started taking it, whereas before that, bronchitis was a yearly concern. Goodbye bronchitis.

    Two nights ago I had another drug-tripping experience like the one in the OP but worse. Now that I have medical through my work I was able to visit a real doctor for a change. There they found that I have many things still wrong with me. I went home from the clinic with eight separate diagnoses. I was rather astounded. I knew I still felt shitty, but I didn't know I felt that shitty. I was prescribed Prednisone and cefuroxime. But the nightmares that resulted from taking this stuff were horrific. I mean truly horrific. But then I was taking many other things besides, including SAMe, so there may have been a drug conflict.

    Consider this dream situation. You're wrapped up in something, helpless. It feels like chicken wire? You don't know. And something is trying to eat you. It can't bite through, but you can feel it constantly gnawing and biting at you at a tremendous rate of speed over various parts of your body, a feeling that is wholly like being tortured.

    My eyes in the dream were closed tight like they were glued together so I couldn't see what it was. But I managed to open them a slit and saw nothing but maybe a chair. Then they closed up again.

    I managed to get my eyes open again and saw what I thought was my mother(?). She was just standing there. My eyes closed again as the torture continued. Then they opened again just in time to see her walk away out of view.

    I'm not normally one for vocalizing my distress. But soon after that point I started screaming for help because it didn't seem like the torture was ever going to end. I screamed for help over and over again until I finally woke up.
    "Everyone has a plan till they get punched in the mouth." Mike Tyson
    “Culture?” says Paul McCartney. “This isn't culture. It's just a good laugh.”

  2. #102
    breaking out of my cocoon SearchingforPeace's Avatar
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    So, you like the SAMe? I have never taken it, though my brother and mother have...

    I have seen hints of negative aspects, what would you say?
    Quote Originally Posted by Archilochus
    The fox knows many things--the hedgehog one big one.
    And I am not a hedgehog......

    -------------------

    Jesus said "Blessed are the peacemakers" not "blessed are the conflict avoiders.....

    9w8 6w5 4w5 sx/so

    ----------------------

    “Orthodoxy means not thinking--not needing to think. Orthodoxy is unconsciousness.”
    ― George Orwell, 1984

  3. #103
    Senior Member Mal12345's Avatar
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    Quote Originally Posted by SearchingforPeace View Post
    So, you like the SAMe? I have never taken it, though my brother and mother have...

    I have seen hints of negative aspects, what would you say?
    I don't know yet. I'm taking a small dose because of the strong way my mind and body react to everything. And I'm taking other things. But there's been no major side effects after 3 weeks and so far I feel a lot better.
    "Everyone has a plan till they get punched in the mouth." Mike Tyson
    “Culture?” says Paul McCartney. “This isn't culture. It's just a good laugh.”
    Likes SearchingforPeace liked this post

  4. #104
    Senior Member Mal12345's Avatar
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    There may be other side effects as well. The University of California's Berkeley Wellness Letter cautioned that SAM-e converts to homocysteine in the body, and high levels of homocysteine may raise the risk of heart disease. For that reason, they suggest that if you take SAM-e, you also take a multivitamin and be sure your diet is rich in fruits and vegetables -- elements in these foods can help lower your homocysteine levels.

    Finally, researchers at the University of Pittsburgh Medical Center who reviewed all of the existing information on SAM-e advised that it "is not without risk of more significant psychiatric and cardiovascular adverse events." Because of these risks and the lack of information on the long-term effects of taking SAM-e, the University of Pittsburgh report suggests that it only be used under a doctor's supervision.


    I should probably make some more dietary changes. Heart disease...
    "Everyone has a plan till they get punched in the mouth." Mike Tyson
    “Culture?” says Paul McCartney. “This isn't culture. It's just a good laugh.”

  5. #105
    breaking out of my cocoon SearchingforPeace's Avatar
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    Quote Originally Posted by Mal12345 View Post
    There may be other side effects as well. The University of California's Berkeley Wellness Letter cautioned that SAM-e converts to homocysteine in the body, and high levels of homocysteine may raise the risk of heart disease. For that reason, they suggest that if you take SAM-e, you also take a multivitamin and be sure your diet is rich in fruits and vegetables -- elements in these foods can help lower your homocysteine levels.

    Finally, researchers at the University of Pittsburgh Medical Center who reviewed all of the existing information on SAM-e advised that it "is not without risk of more significant psychiatric and cardiovascular adverse events." Because of these risks and the lack of information on the long-term effects of taking SAM-e, the University of Pittsburgh report suggests that it only be used under a doctor's supervision.


    I should probably make some more dietary changes. Heart disease...
    Yeah, that was what I had heard.....
    Quote Originally Posted by Archilochus
    The fox knows many things--the hedgehog one big one.
    And I am not a hedgehog......

    -------------------

    Jesus said "Blessed are the peacemakers" not "blessed are the conflict avoiders.....

    9w8 6w5 4w5 sx/so

    ----------------------

    “Orthodoxy means not thinking--not needing to think. Orthodoxy is unconsciousness.”
    ― George Orwell, 1984

  6. #106
    Senior Member Mal12345's Avatar
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    Ok, I've made the dietary changes.
    "Everyone has a plan till they get punched in the mouth." Mike Tyson
    “Culture?” says Paul McCartney. “This isn't culture. It's just a good laugh.”

  7. #107
    Senior Member Mal12345's Avatar
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    After going through the allergy testing, I am now more allergic than ever. For the first time in my life I have a huge rash all over my back. I believe this is because I laid down on top of my bed covers yesterday with no shirt on, which is where the dogs like to lie during the day.

    The allergy clinic has determined that I am not a good candidate for immunotherapy. If I am given any of those injections I will end up in the ER with some kind of reaction, be it asthma or something else.

    My asthma is worse than ever now. A little exercise and I am short of breath because of "exercise asthma." Even getting in bed at night causes me to have to take a few deep breaths in order to keep up oxygen levels.

    It's actually CO2 levels rising in the bloodstream that make a person feel out of breath.
    "Everyone has a plan till they get punched in the mouth." Mike Tyson
    “Culture?” says Paul McCartney. “This isn't culture. It's just a good laugh.”

  8. #108
    Senior Member Mal12345's Avatar
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    The allergy doctor had given me an antibiotic called Ceftin for the sinus infections. They don't have any proof that I have sinus infections. There are other things that can occur in the sinuses to cause pain.

    My first day on Ceftin I ended up with a red face and chest, but for a few days after that there was no problem and I didn't even think it was caused by Ceftin. I tested allergic to 39 out of 50 known allergens, after all.

    After about 10 days on Ceftin I began to feel very strange. After two weeks on Ceftin I went into Urgent Care, which is kind of a pre-ER where doctors (usually PAs) see patients with urgent medical cases that wouldn't normally be considered emergencies.

    I had written down my symptoms prior to driving myself to the Urgent Care. Here is the list I jotted down at the time:

    Stabbing pain in extremities / joints - left elbow, right thigh, right top of foot.
    light-headedness
    eyes roll back - eye lids flutter when trying to focus.
    dizziness
    loud ringing in ears
    sinusitis
    dry cough
    shortness of breath
    itchy derma, throat tickle
    runny nose
    nausea.

    The Urgent Care nurse reported my blood pressure as 155/109. She asked if that was normal for me and I said "no."

    I sat for an hour in the little examination room while I waited for my doctor to show up. I spoke to a nurse during that time and she said the doctor had to accompany a patient to the ER. I don't think the patient wanted to pay for an ambulance, but I don't understand why a nurse couldn't have done that.

    But I made good use of my hour alone in a little room. I figured out that I was reacting to the Ceftin. So when the doctor finally showed up, all apologetic about the wait, I told him that he didn't even have to think because I had worked out the cause of this.

    The doctor took me off Ceftin, obviously, and replaced it with Azithromycin. The next Monday I visited a Primary Health facility where that doctor replaced Azithromycin with Augmentin, a penicillin-based antibiotic to which I may be allergic. Now I'm just waiting to finish the Augmentin to see if my allergies calm down.
    "Everyone has a plan till they get punched in the mouth." Mike Tyson
    “Culture?” says Paul McCartney. “This isn't culture. It's just a good laugh.”

  9. #109
    Senior Member Mal12345's Avatar
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    I spoke with the head honcho of the sinus/allergy clinic about the Ceftin incident. He said that very often the body doesn't react at first. In this case it took 10 days to have a reaction to Ceftin.
    "Everyone has a plan till they get punched in the mouth." Mike Tyson
    “Culture?” says Paul McCartney. “This isn't culture. It's just a good laugh.”

  10. #110
    Senior Member Mal12345's Avatar
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    I researched the head honcho of the sinus and allergy clinic who I spoke to on Oct. 3. He lost his license to practice medicine in the state of California, and has received two warnings from the state he is currently practicing in. They involve ordering unnecessary tests and procedures.

    My health has definitely taken a turn for the worse since the Ceftin incident. There is more body pain than ever. I get strange stabbing pains in my right femur and a little in my left. I have a sit-down job taking tech support calls, and my feet hurt just from sitting there for hours, especially my left foot. Sometimes the ringing in my ear, which was there already, gets so loud now that I can't go to sleep at night. I have recently developed tailbone pain from sitting down. I can't do stand up work, and now it's getting to the point where I can't even do sit-down work. So I've ordered a coccyx pillow from Amazon.

    A few weeks ago I had all my eyeglass lenses upgraded. Three days ago things began to get blurry again already, especially for distance. The second day things were blurrier than the first, and today they are blurrier yet. I had to buy some off-the-shelf reading glasses with just enough power to help me drive with comfortable vision.

    I also get dizzy a lot.
    "Everyone has a plan till they get punched in the mouth." Mike Tyson
    “Culture?” says Paul McCartney. “This isn't culture. It's just a good laugh.”

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