The original plot outline by Roberto Orci and Alex Kurtzman has the following differences from the film: •While the Mary Jane Watson sequences were shot but excluded from the final film, the script establishes Mary Jane as Peter's next door neighbor who has an alcoholic, abusive father, sports a Spider-man tattoo, works as a waitress, and builds motorcycles in her spare time. At one point Peter confronts her father to lay off her. When Gwen is planning to head to London, she gives a piece of dating advice to Mary Jane, telling her to date a nerd, hence signaling her go ahead and get Peter.
•Max originally lives with his handicapped mother at home and once he returned home as Electro, he noticed that his mother was standing and got paid a hefty compensation by Oscorp. He gets angry and begins using his powers, which is what sets off his confrontation with the police in Times Square, not a weird moment where he just starts sucking on electrical wires for no reason.
•J. Jonah Jameson and Robbie Robertson from the Daily Bugle were to appear in the film, but director Marc Webb had difficulty of finding an actor that can better J.K. Simmons' performance in the Sam Raimi Spider-man trilogy. In the script Peter is a student at Empire State University, bringing his first Spider-Man pictures to Jameson, who gives him a tour of the Daily Bugle. Jameson complains that the Internet is killing the newspaper business; later, Spidey and Electro's first fight send them crashing through the Daily Bugle offices and the printing presses.
•Peter willingly gives his blood to help Harry. The Goblin suit is explained as something that was secretly built by Richard Parker for the crippled Norman Osborn. When Richard didn't give his blood to Norman, the suit was hidden in Norman's boathouse, only to be eventually found by Harry.
•Rather than 7 months, as the time period of the film takes place, it instead plays out in 18 months. The second act of the film jumps one year later after the graduation scene, making Peter's forlorn attitude towards Gwen cute instead of creepy, and it establishes that they're in college. This makes Gwen's application to Oxford more logical.
•Dr. Ratha from The Amazing Spider-Man (2012) was meant to reappear in this movie. Although his final scene in that movie left him in mortal peril, the writers insist that he survived that predicament. But Irrfan Khan was unavailable to reprise the role, so the character Donald Menken was introduced to engineer Harry's dismissal from Oscorp in Ratha's place. (Ratha was at one point intended to become the villain Proto-Goblin at some point in the series, but it is now doubtful that this will ever happen. So many different "Goblins" have already appeared in in the Spider-man movies that yet another one would seem redundant.)
•Rhino and Jorge, the little kid, originally do not appear.
•Gwen's death plays out similarly as in the finished film but while she's clinging on to her life, she tells Peter to never give up, echoing both an earlier talk she had with Mary Jane and George Stacy's dying words to Peter in the preceding film.
•Instead of Peter watching Gwen's graduation video at the end, his father Richard turns up alive, saying that he had been watching over Peter all these years he was pretending to be dead, and convinces him to become Spider-man again. Richard says the film's final line, "With great power comes great responsibility", hence providing a nice way of reintroducing Spidey's catchphrase into the new series. A living Richard was likely nixed for being too saccharine and contrary to an essential tenet of Spider-man's mythos, i.e. that he must achieve manhood on his own without any living father figure.