For me it's Home Movies - it's just such a good fit for my brain with its unique brand of droopy silliness.
The first man to raise a fist is the man who's run out of ideas. H.G. WELLS
The first principle is that you must not fool yourself, and you are the easiest person to fool. FEYNMAN If this is monkey pee, you're on your own.SCULLY
I'm somewhat of an anime fan, so the answer keeps changing.
Sill, my answer has been stable for sometim. I would have to say Cowboy Bebop.
It's fun. It's artsy. I like the soundtracks. It has a story arc without being too demanding or sopa-opera'ish.
Accept the past. Live for the present. Look forward to the future. Robot Fusion
"As our island of knowledge grows, so does the shore of our ignorance." John Wheeler
"[A] scientist looking at nonscientific problems is just as dumb as the next guy." Richard Feynman
"[P]etabytes of  data is not the same thing as understanding emergent mechanisms and structures." Jim Crutchfield
As a kid it was Speed Racer. Now I enjoy the more traditional sitcommy ones like The Simpsons, King of the Hill, South Park and Family Guy. I also love Robot Chicken, which is animated but not really a cartoon.